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KMID : 0366919980100010398
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Sungkyun Pharmceutical Journal
1998 Volume.10 No. 1 p.398 ~ p.400
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Stability of Albuterol in Continuous Nebulization
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Hunter, Dee A.
Fox, Janet L./Yoo, Sun D./Michniak, Bozena B.
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Abstract
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Due to the emergent nature of situations requiring continuous nebulization of albuterol, a premixed albuterol solution would provide faster access to the therapy when required. The purpose of this study was to evaluate the stability of albuterol solutions at a concentration (200㎍/mL) used in continuous nebulization when stored in various containers of polyvinyl chloride bags, polyolefin bags, polypropylene syringes and tubes and borosilicate glass tubes. Solutions were prepared in triplicate in 0.9% sodium chloride stored under refrigerated and room temperatures for seven days. Samples were removed and analyzed using a stability-indicating high-performance Liquid chromatography assay method. Albuterol was found to be stable (>90% of the initial concentration remaining) for at least seven days in all five types of containers under the conditions tested.
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